She had worked in Telugu, Kannada, Tamil, Bengali cinema apart from Bollywood. Manjari debuted in Bollywood in 2004 with a role in a flop movie ‘Rok Sako toh Rok Lo’ in 2004. She found popularity in the film ‘Jaane Tu Ya Jaane Na’ as the girl who has a crush on Imran Khan. The movie was a debut vehicle for Imran Khan, back in 2008.
In 2008, she did a couple of South Indian films including Siddu From Srikakulam (Telugu) and Muthirai (Tamil) but both the movies flopped. Interestingly, she had even sung a song for the Tamil movie. She continued doing South Indian films with varying degree of success.
In 2011, Manjari played a role in a movie called Zokkomon. In 2013, Manjari Phadnis had two back to back releases in Bollywood including the successful Grand Masti and a flop, Warning-3D. Manjari has also endorsed products like Onida TV and iBall pen drives.